Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington’s Disease (LCR-MH)

About

The main purpose of this study is to be able to confirm whether a protein called BDNF is a biomarker for the expression of HD in humans. The study will recruit 135 participants who will be followed for a period of 2 years. Their levels of BDNF will be measured in samples taken both from the cerebrospinal fluid (CNF) and blood. The symptom development in the 2 year trial period, will also be monitored with brain imaging and by testing cognitive functions. The study will investigate how the levels of BDNF in the blood and the CSF differ or correspond. The study will also try to identify the connection between BDNF levels and symptom development. Why is this study important? We have good reasons to believe that BDNF has an active role in protecting damaged brain cells as well as enhancing growth of new ones. The study will provide us with more solid information about the connection between BDNF and symptom development in humans with HD. If proven to be relevant, BDNF levels will probably be a target for treatment in the future. In this study the BDNF levels in CSF and blood will hopefully be identified as a biomarker for HD. We need biomarkers to measure if a treatment has positive effect or not.