Win-HD- At a Glance
  • Sponsored by : Institut National de la Santé Et de la Recherche Médicale, France
  • Collaborator: University College, London
  • Official Title: Decoding Presymptomatic White Matter Changes in Huntington Disease
  • Involves: Brain imaging, Neurological assessments, Psychological assessments and Behavioural assessments
  • Study type: Clinical Interventional trial
  • phase: Not applicable 
  • Purpose : WIN-HD is a monocentric longitudinal study comparing premanifest Huntingtin (HTT) mutation carriers and non HTT mutation carriers to determine that white-matter atrophy occurs far earlier than clinical onset in HD using Diffusion-weighted Nuclear Magnetic Resonance (N spectroscopy (DWS) and Diffusion Tensor Imaging (DTI). The investigators will recruit up to 20 premanifest HTT mutation carriers (15 completed) and up to 20 non HTT mutation carriers (15 completed). It is important to have those 2 populations in order to compare our results and determine if there are significant white-matter changes far from the onset of HD
  • Status: completed