BIOHD- At a Glance
  • Sponsored by : Assistance Publique – Hôpitaux de Paris
  • Official Title: Study of Biomarkers That Predict the Evolution of Huntington’s Disease
  • Involves: Neurological, neuropsychological, neuroimaging evaluation and biological sample
  • Study type: Clinical Observational trial
  • phase: Not applicable 
  • Purpose :  In this context, we propose to focus our research not only on biological and genetic markers but also on neuroimaging and neuropsychological markers using paradigms of time reactions or measurement of evoked potentials. We hope to identify sensitive markers of the degenerative process of Huntington’s disease even when patients carrying the gene may or may not have reported the disease. The project is centered on 2 axes: 1. identification of the genetic polymorphism which may explain the phenotypic variability seeing in Huntington’s disease 2. identification of biological, genetic and imaging biomarkers that could be used as predictors of clinical progression of Huntington’s disease
  • Status: see trial sites below for details on recruitment status

 

Eligibility Criteria

Ages Eligible for Study:  18 Years and older  (Adult, Older Adult)
Sexes Eligible for Study:  All
Accepts Healthy Volunteers: Yes

 

 

Inclusion Criteria

Inclusion Criteria (patient):

  • Voluntary patients symptomatic or asymptomatic
  • Patient with a number of CAG ≥36)
  • Patient who know his genetic status
  • Age greater than 18 years or equal to 18 years
  • Patient who provided written informed consent

Inclusion Criteria (control):

  • Voluntary controls with no family history of huntington’s disease
  • Control with a number of CAG <36
  • Age greater than 18 years or equal to 18 years
  • Control who provided written informed consent

Exclusion Criteria

 

Exclusion Criteria (patient):

– Deterioration of the protocol preventing the understanding of the protocol

Exclusion Criteria (control):

– Deterioration of the protocol preventing the understanding of the protocol

 

 

TRIAL SITES

 

FRANCE

 

Trial site: Hôpital Henri Mondor

 

Status:Recruiting 

Address: Creteil, France, 94010

 

 

Contact: Bachoud-Lévi Anne-Catherine, PH 

 

Telephone: (0)1 49 81 23 01 ext +33  

 

Email: bachoud@gmail.com