DOMINO-HD
Not recruiting
UPDATES:
Recruitment for this EU-funded observational study, which is designed to provide new insights into whether behaviour and lifestyle factors are linked to HD genetic risk and progression, finally got underway in February following delays caused by the pandemic.
DOMINO-HD is split into two phases; phase 1 is looking at methods for reliably measuring lifestyle factors (physical activity, sleep, diet) in people with Huntington’s disease (HD) in a way that disrupts their normal life as little as possible. Phase 2 will use the information gathered in phase 1 to measure these lifestyle factors in people with HD over 12 months. The main purpose of DOMINO-HD is to look at how sleep, nutrition and physical activity impacts the progression of Huntington´s disease so as to develop new ways to support and manage fundamental aspects of HD patients. The study will also explore how digital technologies, such as wearable fitness trackers, can be used to support people with HD.
Estimated Study Completion Date: March 2022
Ages Eligible
for Study:
18 Years and older
(Adult, Older Adult)
Sexes Eligible
for Study:
All
Accepts Healthy Volunteers:
Gene positive
Inclusion Criteria
Adults (aged over 18 years) with a diagnosis of Huntington’s Disease confirmed by genetic testing, who are able to walk unassisted and are participating (current or newly enrolled) in the Enroll-HD study.
Exclusion Criteria
- Diagnosis of juvenile onset Huntington’s Disease (HD)
- History of co-morbid neurological conditions such as multiple sclerosis or stroke
- Acute (within 1 month) orthopaedic conditions such as an ankle sprain or fracture
- Severe medical conditions such as unstable or progressive heart disease, uncontrolled diabetes, severe liver, kidney or thyroid dysfunction, or similar medical conditions
- Any acute or unstable psychiatric condition
- Unable to tolerate long-term wear of activity monitor
- Inability or unwillingness to give written informed consent
- No access to a smartphone
- Not willing to allow the research team to install Apps on their smartphone related to the study
LOCATIONS
General enquiries
Cheney Drew
Tel: +44 (0)29 2068 7243
drewc5@cardiff.ac.uk
GERMANY
IRELAND
TRIAL SITE:
Universitätsklinikum Ulm
Address: Ulm, Baden-Württemberg, Germany, 89081
CONTACT
Nana Kovacevic
nana.kovacevic@uniklinik-ulm.de
Recruiting
TRIAL SITE:
University College Dublin, Ireland
Address: University College Dublin, Belfield, Dublin 4, Irland
CONTACT
Madeleine Lowery
Tel: +353 1 716 1911
madeleine.lowery@ucd.ie
Recruiting
POLAND
SPAIN
TRIAL SITE:
Institute of Psychiatry and Neurology, Warsaw
Address: Jana III Sobieskiego 9, Warszawa, 02-957
CONTACT
Malgorzata Dusza-Rowinska
Tel: +48 694 904 208
m.dusza.rowinska@gmail.com
Recruiting
TRIAL SITE:
Hospital Universitario de Burgos
Address: Neurology Department, Avda Islas Baleares 3, Burgos, 09006
CONTACT
Carla Collazo
Tel: 947 256 533 ext 35380
ccollazo@ubu.es
Recruiting
SWITZERLAND
UNITED KINGDOM
TRIAL SITE:
University Hospital Zurich
Address: Zürich, Switzerland, 08091
CONTACT
Hans Jung
hans.jung@usz.ch
Klavs Renerts
klavs.renerts@usz.ch
Recruiting
TRIAL SITE (Lead site):
Cardiff University
Address: Cardiff, United Kingdom, CF24 4HQ
CONTACT
Philippa Jones
Tel: +44 29206 87269
dominohd@cardiff.ac.uk