Here you will find webpage news and updates related to Huntington Disease clinical trials and studies.
– May 12th, 2023
WEBINAR VIDEO 🟢 PROOF-HD study good and less good news
On April 25th, Prilenia announced results from the PROOF-HD clinical trial for Huntington’s Disease. Some of the participants showed significant benefits from the Pridopidine drug, while others did not benefit at all.
The European Huntington Association, in collaboration with Prilenia, organized a Webinar to talk about the preliminary study results from the phase 3 PROOF-HD study and what they mean.
Listen to Dr Michael Hayden (founder and CEO of Prilenia), Dr Ralf Reilman (Principal Investigator for PROOF-HD in Europe) and Dr. Andrew Feigin (Chair at The Huntington Study Group) explaining the results and indicating further steps.
– May 11th, 2023
There has been an amendment to the PIVOT HD trial entry criteria
We just updated the inclusion criteria for PIVOT HD, the PTC Therapeutics Phase II clinical trial.
- Length of trial from 12 weeks to 12 months
- CAG repeat length was previously 42-50 and is now 40-50
- Number of subjects was previously 162 an is now up to 252
- We are recruiting Stage II AND Stage 3 now (so TFC and/or Independence scale less than 13/100)
– April 25th, 2023
Prilenia announce results from the PROOF-HD study
Prilenia announce results from the PROOF-HD study: Promising, but mixed results!
Some of the participants showed significant benefits from the Pridopidine drug, while others did not benefit at all. This is promising because, for the first time, we have a drug that demonstrates effect on disease progression, cognitive and motor symptoms.
After the announcement, the European Huntington Association organized a Webinar with Dr Michael Hayden, founder and CEO of Prilenia, who will explain the results and indicate further steps.
– March 20th, 2023
WEBINAR VIDEO: Novartis Discusses the VIBRANT-HD Trial
The European Huntington Association, in collaboration with Novartis, organized a Webinar to learn more about VIBRANT-HD trial and the decision to stop the development of branaplam in Huntington’s Disease.
The webinar speakers included VIBRANT-HD clinical site investigator and Steering Committee member, Bernhart Landwehrmeyer, Medical lead for the branaplam program, Dr. Harry Ramos, and Clinical program head for the branaplam program, Dr. Beth Borowsky.
– January 19th, 2023
WEBINAR: Updates of Wave's clinical trial SELECT-HD
The European Huntington Association, in collaboration with Wave, organized a Webinar on the updates of Select-HD clinical trial for Huntington’s disease.
Dr. Ralf Reilmann, founder of the George-Huntington Institute in Muenster, presented an overview of the SELECT-HD trial, which is looking at the safety of the investigational molecule called WVE-003. After his presentation, we had a Q&A session with Danlin Xu, HD Medical Director at Wave, and Marissa Volpe, HD Program Lead at Wave.
– January 12th, 2023
WEBINAR: Updates from Roche on Phase II GENERATION HD2 study for Huntinton's Disease
The GENERATION HD2 clinical trial is just about to start recruiting participants in the first of a total of 15 countries and 9 of them are in Europe: Denmark, France, Germany, UK, Poland, Italy, Spain, Portugal and Switzerland. The study aims to enroll 360 participants and evaluate the safety of the investigational drug tominersen in people with early manifest HD.
– January 11th, 2023
EFNA's new eLearning initiative on research
The online course aims to upskill participants on how they can effectively advocate in a virtual world by identifying and engaging key stakeholders and developing partnerships, hosting successful online events and developing and disseminating key advocacy messages.
– December 16th, 2022
Updates from SOM Biotech
We met with Dr Catherine Scart, Chief Medical Officer at Som Biotech, and we asked her some questions about the new Phase 2b trial for Huntington’s Disease (HD) called SOM3355.
– December 12th, 2022
We moved VIBRANT-HD to the completed trials section
Novartis ends the VIBRANT-HD study and will not continue the program with Branaplam.
– December 11th, 2022
Check our new Webinar section!
We have compiled all the European Huntington Association recent webinars in a new section that you can find in the menu of the webpage.
– December 11th, 2022
We have adapted the HDTrial Finder dictionary to make it easier and more convenient by including it on the different clinical trial pages. Simply click on the highlighted words to find an easy definition.