SELECT HD
Recruiting
The study is a Phase 1/2 and will look at the safety and how participants tolerate a new antisense oligonucleotide(ASO) in early stage disease, called WVE-003.
WVE-003 is a new investigational molecule that tries to reduce the toxic mHTT protein (while avoiding targeting the healthy, wild-type huntingtin protein, and preserving its beneficial effects in the central nervous system).
Learn more about the trial in our upcoming webinar
Webinar with Wave on the updates of SELECT-HD clinical trial
Danlin Xu presents updates on SELECT-HD trial
Ages Eligible
for Study:
25 Years to 60 Years
Sexes Eligible
for Study:
All
Accepts Healthy Volunteers:
No
- Presence of the A variant of SNP3 on the same allele as the pathogenic CAG triplet expansion
- Ambulatory, male or female patients aged ≥25 to ≤60 years
- Clinical diagnostic motor features of HD, defined as Unified Huntington’s Disease Rating Scale (UHDRS) Diagnostic Confidence Score = 4
- UHDRS Total Functional Capacity Scores ≥9 and ≤13
- Malignancy or received treatment for malignancy, other than treated basal cell or squamous cell carcinoma of the skin, within the previous 5 years
- Received any other study drug, including an investigational oligonucleotide, within the past 1 year or 5 half-lives of the drug, whichever is longer, with the exception of the following: Received WVE-120101 or WVE-120102 within the last 3 months.
- Implantable CNS device that may interfere with ability to administer study drug via lumbar puncture or undergo MRI scan
- Inability to undergo brain MRI (with or without sedation)
- Bone, spine, bleeding, or other disorder that exposes the patient to risk of injury or unsuccessful lumbar puncture
LOCATIONS
COUNTRIES
Denmark
- TRIAL SITE:Rigshospitalet
- Address:Copenhagen, Denmark, 2100
- Principal Investigator: Lena Hjermind, MD
France
- TRIAL SITE: Hopital Henri Mondor – Hospital
- Address: Créteil, France, 94010
- Principal Investigator: Katia Youssov, MD
- TRIAL SITE:Institut du Cerveau et de la Moelle Epiniere
- Address: Paris, France, 75646
- Principal Investigator: Alexandra Durr, MD, PhD
Germany
- TRIAL SITE: Katholisches Klinikum Bochum gGmbH
- Address: Bochum, Germany, 44791
- Principal Investigator: Carsten Saft, MD
- TRIAL SITE: George-Huntington-Institut GmbH
- Address: Muenster, Germany, 48149
- Principal Investigator: Ralf Reilman, MD
- TRIAL SITE: kbo-Isar-Amper-Klinikum Taufkirchen (Vils)
- Address: Taufkirchen, Germany, 84416
- Principal Investigator: Alzbeta Mühlbäck, MD
Italy
- TRIAL SITE: Centro Ricerche Cliniche Di Verona
- Address: Verona, Italy
- Principal Investigator: Tomasso Bovi, MD
Poland
- TRIAL SITE: Szpital Sw. Wojciecha
- Address:Gdańsk, Poland, 80-462
- Principal Investigator: Jaroslaw Slawek, MD
- TRIAL SITE: Instytut Psychiatrii I Neurologii
- Address:Warsaw, Poland, 02-957
- Principal Investigator: Grzegorz Witkowski, MD, PhD
Spain
- TRIAL SITE: Hospital de la Sanata Creu i Sant Pau
- Address: Barcelona, Spain, 08041
- Principal Investigator: Jaime Kulisevsky, MD, PhD
- TRIAL SITE: Hospital Universitario Ramón y Cajal
- Address: Madrid, Spain, 28034
- Principal Investigator: Jose Luis Lopez-Sendon Moreno, MD
UK
- TRIAL SITE: Royal Liverpool University Hospital
- Address: Liverpool, United Kingdom, L7 8XP
- Principal Investigator: Richard Rhys Davies, MA BMBCh PhD FRCP
- TRIAL SITE:Royal Liverpool University Hospital
- Address: Liverpool, United Kingdom, L7 8XP
- Principal Investigator: Richard Rhys Davies, MA BMBCh PhD FRCP
- TRIAL SITE: Cardiff University, Schools of Medicine and Biosciences
- Address: Cardiff, Wales, United Kingdom, CF14 4XW
- Principal Investigator: Anne Rosser, PhD, MBBChir, MRCP
- TRIAL SITE: Royal Hospital for Children, Pharmacy Aseptic Unit
- Address:Glasgow, Glasgow City, United Kingdom, G51 4TF
- Principal Investigator: Matthew Sheridan
- TRIAL SITE: Royal Victoria Infirmary
- Address: Newcastle, United Kingdom
- Principal Investigator: Suresh Komati, MD
